[Evaluation of intraperitoneal use of sodium carboxymethylcellulose solution for prevention of experimentally induced abdominal adhesions in donkeys]

ABSTRACT

The present study was conducted to evaluate the of intraperitoneal use of sodium carboxy-methylcellulose solution [1% and 2% ] in prevention of experimentally induced abdominal adhe-sion. 15 healthy adult donkeys were allocated in 3 groups each of 5 animals. Group I as control while group II and III used as treated roups. In control group, donkeys were treated a sterile solution of sodium chloride 0.9% jintraperitoneally. In treatment groups, donkeys [were treated with a sterile solution of sodium car-boxymethylcellulose [SCMC] in a dose of 7 ml/ kg of body weight intraperitoneally in concentra-on of 1% for group II and 2% for group III. After end of the experimental period, histopatholog-examination was done to all groups. Results aled intraabdominal adhesions associated lith abraded, anastomotic sites and a distant seg-of jejunum in all cases of control group. In treated donkeys with 1% SCMC solution, there were no adhesions detected in 4 donkeys but one case had adhesion between the jejunal abrasion site and the adjacent peritoneum. No adhesion was noticed at the anastomotic sites. In treated donkeys with 2% SCMC solution, all cases had ecchymotic serosal hemorrhage at abrasion sites and mesentery with developed peritonitis