Assessment of insulin resistance in type 2 diabetic subjects at a tertiary care hospital of Karachi Pakistan

ABSTRACT

During the last few decades there has been a surge of interest in the assessment of insulin resistance. Our study aims to identify the insulin resistance in type 2 diabetic population so that we might be able to identify insulin resistance easily in daily routine clinical practice. All type 2 diabetic subjects having age 30 years or more are selected with exclusion criteria [hepatic, renal or cardiac impairment]. After taking informed consent from the patients fasting blood samples were taken. Assessment of insulin resistance was done by homeostasis model assessment HOMA. HOMA-R = Insulin [mu/ml] x glucose [mmol/1]/22.5 All statistical analyses were performed using the statistical program SPSS [version 11] A Total of 118 subjects were recruited in the study. Mean age of subjects was 49.1 +/- 10.2 years. Mean BMI was 27.8 +/- 4.9 kg/m2o Subjects comprising of 62.4% males and 37.6% females. Mean HOMA in our Type 2 diabetic subjects was 4.1 [male 4.41 and female 3.73]. In our study 73.7% subjects has HOMA value of 1. 77 or more, while 57% have HOMA value of 2.8 or more