Synthesis of some novel chromenopyrimidine derivatives and evaluation of their biological activities
IJPR-Iranian Journal of Pharmaceutical Research. 2014; 13 (3): 873-879
em Inglês
| IMEMR
| ID: emr-196701
ABSTRACT
Pyrimidine nucleosides are constituents of fundamental structure of the cells. There has been considerable attentions in the chemistry of pyrimidine derivatives due to having a wide range of biological activities such as antiviral, anti-malarial agents, cytostatic, antithelemintic, antibacterial, adenosine receptor ligands, anti-cancer agents, compounds targeting delayed-type hypersensivity and anti-convulsant agents. As a part of our research work in the synthesis of pyrimidines containing biological activities, a series of chromenopyrimidine derivatives were synthesized by reaction of an intermediate imine and ammonia derivatives in good to high yields. All synthesized compounds were characterized using IR and NMR [1H and 13C] spectroscopy and elemental analysis data. The antibacterial activity of these compounds was investigated against Staphylococcus aureus [RTCC, 1885], and Escherichia Coli [ATCC, 35922]
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Índice:
IMEMR (Mediterrâneo Oriental)
Idioma:
Inglês
Revista:
Iran. J. Pharm. Res.
Ano de publicação:
2014
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