Haplotype frequency of G691S/S904S in the RET proto-oncogene in patients with medullary thyroid carcinoma

ABSTRACT

Background: Medullary thyroid carcinoma [MTC] occurs in both sporadic [75%] and hereditary [25%] forms. The missense mutations of the RE arranged during Transfection [RET] proto-oncogene in MTC development have been well demonstrated. The aim of this study was to investigate frequency of G691S/S904S haplotype in MTC patients and their relatives