Scavenger receptor class B Type 1 gene polymorphism and the risk of premature coronary artery disease

ABSTRACT

Background: Coronary artery disease [CAD] is one of the greatest causes of morbidity and mortality worldwide. It is the principal threat to health in countries in Africa and the Middle East and one of the leading causes of disease burden in developing countries. Scavenger receptor class B type1 [SCARB1] is a multiligand cell surface receptor. This membrane protein facilitates the uptake of cholesterol esters from highdensity lipoprotein cholesterol [HDL-C] and drives cholesterol from tissues to the liver in the various stages of reverse cholesterol transport pathway