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Prevention of transcriptional gamma-globin gene silencing by inducing the hereditary persistence of fetal hemoglobin point mutation using chimeraplast-mediated gene targeting
Cell Journal [Yakhteh]. 2018; 20 (3): 318-325
em Inglês | IMEMR | ID: emr-197609
ABSTRACT

Objective:

Hemoglobin F [HbF] augmentation is considered a clinically beneficial phenomenon in beta-hemoglobinopathies. Prevention of gamma-globin gene silencing, inspired by the hereditary persistence of fetal hemoglobin, may be a suitable strategy to upregulate HbF expression in these patients. Therefore, our objective was to assess the potential feasibility of induced -117 G?A substitution in HBG promoter in prevention of transcriptional silencing of the gamma-globin
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Índice: IMEMR (Mediterrâneo Oriental) Idioma: Inglês Revista: Cell J. [Yakhteh] Ano de publicação: 2018

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Índice: IMEMR (Mediterrâneo Oriental) Idioma: Inglês Revista: Cell J. [Yakhteh] Ano de publicação: 2018