Possible involvement of epstein-barr virus [EBV] in pathogenesis and prognosis of female breast infiltrating duct carcinoma: clinicopathological, immunohistochemical and molecular study

ABSTRACT

Background: Recent studies have raised the possibility that EBV may be involved in the pathogenesis of breast carcinoma. Many studies have shown that membrane type-1 matrix metalloproteinase [MT1-MMP] has an important role in matrix metalloproteinase type2 [MMP-2] activation in cell membranes but only few reports about its clinical value are valid. In this study, we investigated the relationship between MT1-MMP protein expression and MMP2 activity as well as EBV infection