Nucleolar organizer regions in normal bone marrow

ABSTRACT

The silver colloid technique for nucleolar organizer regions [AgNORs] was applied to bone marrow smears in 20 cases of normal morphology marrow. The AgNORs were recorded in the form of 'clusters' and 'dots'. Each developing cell type of myeloid and erythroid series revealed a different pattern of 'clusters' and 'dots'. 'Clusters' associated with proliferation while mature, non-dividing forms contained only 'dots'. 'Clusters' and 'dots' have different biologic significance and the method should be adopted while evaluating marrow smears