De novo balanced robertsonian translocation rob[22;22][q10;q10] in a woman with recurrent pregnancy loss: a rare case

ABSTRACT

Background: Recurrent pregnancy loss [RPL], one of the most common complications of pregnancy, is responsible for significant emotional distress to the couple desiring to conceive. In almost 50% of the cases, the etiology remains unknown. The frequency of chromosomal structural rearrangements associated with a history of RPL in couples varies between 2% to 8%. Robertsonian translocations [ROBs] have an estimated incidence rate of 1/1000 births, making this type of rearrangement the most common structural chromosomal abnormalities seen in the general population. According to the literature, there are few RPL cases with rob [22; 22]