Subtelomeric rearrangements in patients with recurrent miscarriage

ABSTRACT

Background: The subtelomeric rearrangements are increasingly being investigated in cases of idiopathic intellectual disabilities [ID] and congenital abnormalities [CA] but are also thought to be responsible for unexplained recurrent miscarriage [RM]. Such rearrangements can go unnoticed through conventional cytogenetic techniques and are undetectable even with high-resolution molecular cytogenetic techniques such as array comparative genomic hybridization [aCGH], especially when DNA of the stillbirth or families are not available. The aim of the study is to evaluate the rate of subtelomeric rearrangements in patients with RM