antifibrotic potential of resveratrol in schistosoma mansoni -infected mice

ABSTRACT

Schistosoma mansoni infection continues to be one of the most serious parasitosis worldwide due to its debilitating effects, mainly hepatic fibrosis. The present study explored the antifibrotic effect of resveratrol [RSV], either alone or in combination with praziquantel, on the murine model of intestinal schistosomiasis. We performed two parallel experiments exploring the preventive and the curative effect of RSV on inflammation and fibrosis. Parasitological measurements [adult worm burden, oogram], biochemical [AST, ALT, hydroxyproline], histopathological and histobiochemical studies were performed. The results revealed that RSV has significant curative and preventive outcome on hepatic fibrosis and this effect is augmented when coupled with praziquantel. Other parasitological and biochemical parameters were enhanced as well