C-565T polymorphism [rs2422493] of the ATP-binding cassette transporter A1 gene contributes to the development and severity of coronary rrtery disease in an Iranian population

ABSTRACT

Objectives: ATP-binding cassette transporter A1 [ABCA1] plays a pivotal role in reverse cholesterol transport from peripheral tissues back to the liver. Abnormalities in ABCA1 function may lead to dyslipidemia and coronary artery disease [CAD]. We investigated the role of C-565T [rs2422493] promoter polymorphism of ABCA1 gene in the development and severity of CAD in an Iranian subpopulation