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Synthesis of new pyrimidine and pyrido[2,3-D]pyrimidine derivatives with evaluation of antitumor activity
Egyptian Pharmaceutical Journal [National Research Center]. 2006; 5 (1): 45-60
em Inglês | IMEMR | ID: emr-201417
ABSTRACT
The carbothioamide derivatives of 6-aminopyrimidine-2,4-[1H,3H]dione [2a-c] were prepared by the reaction of different isothiocyanates with 6-aminopyrimidine-2,4-[1H,3H]-dione [1]. Also, azo derivatives of pyrimidine-2,4-diont [3a-d] were obtained, while the Mannich bases [4a,b] were produced by the reaction of compound 1 with formalin and p-aminobenzene sulfonamide derivatives [sulfa drugs]. Pyrimido[4,5-d]pyrimidine sulfonamide [5] was prepared by the reaction of compound 1 with excess of formalin solution and sulfadiazine. Furthermore, compound 1 was condensed with some aromatic aldehydes to give the Schiff's bases [6a-d] which on treating compounds [6b,d] with chloroacetylchloride gave compounds [7a,b].The pyrido[2,3-d]pyrimidine derivatives [8a-c, 9a-c, 10a-d] and [11a-c] were also synthesized. The antitumor activity of some of the synthesized compounds was evaluated
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Índice: IMEMR (Mediterrâneo Oriental) Idioma: Inglês Revista: Egypt. Pharm. J. [NRC] Ano de publicação: 2006

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Índice: IMEMR (Mediterrâneo Oriental) Idioma: Inglês Revista: Egypt. Pharm. J. [NRC] Ano de publicação: 2006