Tumour necrosis factor-alpha gene expression in chronic Hepatitis C virus infection

ABSTRACT

Objective: Tumour necrosis factor [TNF]-alpha, a prototype proinflammatory cytokine, has been implicated as an important pathogenic mediator in a variety of liver conditions. Some genetic polymorphisms in the human TNF-alpha promoter region, such as the G-A transitions -308 and - 238, have been shown to influence TNF-alpha expression in chronic hepatitis C virus infection