Association between rs6759298 and ankylosing spondylitis in iranian population

ABSTRACT

Background: Ankylosing Spondylitis [AS] is a chronic autoinflammatory Spondyloarthropathy [SpA] which is characterized by sacroiliitis, which progresses to the axial skeleton. It seems that non-Human Leukocyte Antigen [HLA] and also HLA-B27 are associated with the susceptibility and pathogenesis of the disease. The recent Genome- Wide Association Studies [GWASs] have reported intergenic rs6759298 to be associated with AS etiology. The aim of this study was investigation of the rs6759298 polymorphism in Iranian AS patients. In addition, probable correlations with clinical indices and manifestations were considered