Frozen thawed embryo transfer cycles; a comparison of pregnancy outcomes with and without prior pituitary suppression by GnRH agonists: an RCT

ABSTRACT

Background: To perform an in-vitro fertilization cycle, pretreatment with gonadotropin-releasing hormone [GnRH] agonist is widely used as a part of controlled ovarian hyper-stimulation protocols to prevent endogenous luteinizing hormone surge and spontaneous ovulation. GnRH agonist pretreatment is relatively costly and there is a risk of hypo estrogenic side effect. It would also lengthen the preparation period until pituitary desensitization occurs