Efficacy and safety of amphotericin B with autologous serum for fungal corneal ulcer

Objective: To observe the clinical efficacy and safety of injection therapy of amphotericin B combined with autologous serum in the treatment of fungal corneal ulcer

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Study Design: An experimental study

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Place and Duration Of Study: Department of Ophthalmology, Jinan Second People's Hospital, Shandong Province, China, from July 2013 to June 2017

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Methodology: Patients diagnosed with monocular fungal corneal ulcer were divided randomly into observation group and control group, 48 cases in each group. Control group was treated with amphotericin B alone. Observation group was treated with autologous serum injection on the basis of the control group treatment. The improvement time of clinical symptoms such as hypopyon, corneal ulcer, foreign body sensation and photophobia were observed in two groups. The clinical efficacy and adverse reactions were compared between the two groups

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Results: The total effective rate of the observation group was higher than that of the control group [p=0.011]. After treatment, the improvement time of the symptoms such as hypopyon, corneal ulcer, foreign body sensation, and photophobia was shorter in the observation group than the control group [all p <0.001]. There was no significant difference in adverse reaction rate between the two groups [p=0.557]

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Conclusion: Injection therapy of amphotericin B combined with autologous serum has significant efficacy for fungal corneal ulcer, which can effectively improve the clinical symptoms with fewer adverse reactions and safe and reliable results, thus worthy of promotion