Evaluation of FTO rs9939609 and MC4R rs17782313 polymorphisms as prognostic biomarkers of obesity: a population-based cross-sectional study

ABSTRACT

Objectives: Obesity is a significant risk factor for a number of chronic diseases, including diabetes, cardiovascular diseases, and cancer. Obesity usually results from a combination of causes and contributing factors, including genetics and lifestyle choices. Many studies have shown an association of single nucleotide polymorphisms [SNPs] in the fat mass and obesity-associated [FTO] and the melanocortin-4 receptor [MC4R] genes with body mass index [BMI]. Therefore, recognizing the main genes and their relevant genetic variants will aid prediction of obesity risk. The aim of our study was to investigate the frequency of rs9939609 and rs17782313 polymorphisms in FTO and MC4R genes in an Iranian population