Induction effects of bacteroides fragilis derived outer membrane vesicles on toll like receptor 2, toll like receptor 4 genes expression and cytokines concentration in human intestinal epithelial cells

ABSTRACT

Objective: Gastrointestinal [GI] tract, like other mucosal surface, is colonized with a microbial population known as gut microbiota. Outer membrane vesicles [OMVs] which are produced by gram negative bacteria could be sensed by Toll like receptors [TLRs]. The interaction between gut microbiota and TLRs affects homeostasis and immune responses. In this study, we evaluated TLR2, TLR4 genes expression and cytokines concentration in Caco-2 cell line treated with Bacteroides fragilis [B. fragilis] and its OMVs