Relation between circulating monocyte chemoattractant protein-1 and early development of nephropathy in type 1 diabetes in children and adolescents

ABSTRACT

Background: nephropathy and renal failure are considered as one of the major complications of diabetes. Microalbuminuria is regarded as the earliest clinical sign of incipient nephropathy. A causal relationship between chronic hyperglycemia and diabetic microvascular disease has been established by various studies