Cyclosporine A in experimental trichinosis: parasitological study

ABSTRACT

During the last few years, antiparasitic effects has been related to the immunosuppressant cyclosporin A [CsA]. This work was planned to study the effect of this drug against different aspects of experimental trichinosis. The work included three experiments. The first experiment was to study the effect of [CsA] on infection when administered to mice at different durations i.e. post infection as well as before and on the same day of infection. It proved to be most effective when given on the same day of infection as evidenced by the significant reduction in adult count, length of female, larval count and index of reproductive capacity [RCI]. However, the effect though still significant, diminished when the drug was given pre- and post- infection. The second experiment was to study the effect of [CsA] on infectivity of the T. spiralis larvae treated either in vivo or in vitro. The results showed that the drug has marked effect in that part of the study as shown by the reduction in all parameters of assessment .The third experiment demonstrated the challenge that followed [CsA] treated primary compared to that of non treated one. Results showed significant reduction in all values. These results evoke ideas for further designs of other treatment and control stratigies for the disease