[Genetics of type 1 diabetes: study of TNF-alpha gene]

ABSTRACT

Background: type 1 diabetes [T1DM] is an organ specific auto-immune disease, which is resulted by selective destruction of islet cells. Insulitis as the initial event prior to T1DM development is featured mainly by lymphocytic infiltration, that may recede frequently leading to healthy state [benign insulitis]. Among the issues that govern which of these outcome lie ahead in insulitis are the genetic background of the host and also the immunological circumstances in islets' micro-environment