Immunopathologic study of fixed drug eruption

ABSTRACT

Objectives: Fixed drug eruption is a common distinct variant of druginduced dermatoses. Although effector and regulatory T cells play roles in the progression and resolution of FDE, respectively, little in- vivo data exist regarding the T cell dynamics in the pathogenesis of FDE. The aim of this study was to through some light on the pathogenesis of FDE through in-situ study of the immunostaining with CD4, CD8 and HLA-DR. Design: Thirty patients with FDE, [16 females and 14 males], their ages ranged between 6 and 54 years with mean 19.6 years old, were included in this study, in addition to 10 normal, age and sex matched, control subjects Settings Dermatology and Pathology Departments, Menoufiya Faculty of Medicine