Clinical application and effect of dexmedetomidine in combination with continuous positive airway pressure on one-lung ventilation in lung surgery of elder patients

ABSTRACT

In this study, 126 elder patients who underwent thoracic surgery under general anesthesia were divided into three groups randomly, i.e. dexmedetomidine group, positive ventilation group and combination group. All patients received varying strategies in addition to the one-lung ventilation, and changes in oxidative stress and indicators of inflammation at different time points were observed. In comparison to the dexmedetomidine group and the positive ventilation group, patients in the combination group at T2-3 had lower levels of malonaldehyde, cortisol, C-reaction protein, interleukin-6 [IL-6] and tumor necrosis factor alpha in serum [p<0.05]; one day after surgery, the incidence of complications in lungs of patients in the combination group was significantly lower than those in the dexmedetomidine group and the positive ventilation group [p<0.05]. Dexmedetomidine in combination with continuous positive airway pressure can alleviate the oxidative stress and inflammation of lung tissues in one-lung ventilation during the thoracic surgery of elder patients, thus, reducing the incidence of postoperative complications