Effect of natural and synthetic sweetners on serum lipids and glucose of alloxan diabetic rats

ABSTRACT

The effect of feeding different levels of natural sweeteners [sucrose, fructose, manitol] and synthetic sweeteners [aspartame] on serum lipid and glucose of alloxan diabetic rats was investigated. Feeding the sweeteners continued for 28 days. The Serum glucose levels revealed significant increase in diabetic control and diabetic control fed sucrose. Aspartame showed significant decrease in serum glucose at low level, while at the high level produced insignificant decrease. In this respect, fructose showed the best results for lowering serum glucose level. Feeding manitol produce significant decrease in serum triglycerides, while aspartame and fructose revealed insignificant increase, the highest value for serum triglycerides was given by sucrose diet. On the other hand, sucrose and aspartame showed significant decrease in serum cholesterol levels, whereas manitol and fructose groups [revealed insignificant increase. Rats fed sucrose and aspartame showed significant decrease in High Density Lipoproteins [HDL] cholesterol levels, meanwhile, manitol produced significant increase. Low Density Lipoproteins [LDL] was significantly reduced on feeding manitol and aspartame, while fructose group showed insignificant decrease. Sucrose group showed high significant increase in LDL cholesterol. Serum total lipids were increased in sucrose and aspartame groups. Manitol and fructose groups revealed significant decrease in total lipids