study of Th1/Th2 cytokine profiles [IL-10, IL-12, IL-4, and IFNgamma] in PBMCs of patients with multidrug resistant tuberculosis and newly diagnosed drug responsive cases

ABSTRACT

Background: Multi-drug resistant tuberculosis [MDR-TB], which is a worldwide clinical problem, is associated with high morbidity and mortality, as well as long-term survival of infected immunocompetent patients. In this study, the PPD-induced production of IL-12, IL-10, IFNgamma, and IL-4 in peripheral blood mononuclear cells [PBMC] from patients with MDR-TB were investigated and compared with cytokine production capabilities in newly diagnosed, treated cases