Antidiabetic property of azadirachta indica; a molecular approach

ABSTRACT

Diabetes mellitus [DM] is a metabolic syndrome, in which there is chronic high blood glucose level. Amongst non-communicable diseases [NCD], type II Diabetes Mellitus is not only the most prevalent disease but its global burden is increasing rapidly. If the blood glucose level is not maintained appropriately, there is a high probability of the development of both macro-vascular as well as microvascular compli-cations. Multiple antidiabetic drugs are in line, but they fail to give long-term control of hyperglycemia, on the other hand these drugs have side effects as well. So there is a need to switch to natural products. The herbal extracts like Azadirachta indica [Neem] is well known for its powerful antioxidant, anti-inflammatory, antipyretic, antimicrobial and antidiabetic properties. It causes hypoglycemia and peroxi-dation of lipid metabolites while increasing the enzymatic activities of glutathione perox-idases, catalases and superoxide dismutases to enhance the antioxidation