Characterization of nucleolar organizer regions [NORs] in benign and malignant epithelial breast lesions

ABSTRACT

This study was conducted on 36 benign and 36 malignant epithelial lesions.They were processed as paraffin sections and attained with 1] Hx. and E. for a-Histopathological typing of the different lesions b- Histopathological grading of the malignant lesions 2] Argyrophil silver colloid technique for NORs demonstration It has been shown that, in the present study, NORs can differentiate between benign and malignant lesions, a finding which facilitate the resolution of some well-known diagnostic problems in the breast. The rapidity of the method of staining, the ease of interpretation and being inexspensive add advantages to it. Moreover, NORs number in malignant lesions can provide an information about the proliferative status of the cells and so it can be used as a prognostic factor supplementary to other prognostic indices in breast carcinoma