Alpha esterase enzyme in liver of rabbits infected with fasciola gigantica and treated with bithionol

ABSTRACT

Alpha esterase in the liver was the subject of histochemical and biochemical studies. The biochemical study confirmed the histochemical study. It was found that bithionol therapy was accompanied by a marked increase in alpha esterase activity in normal liver rabbits receiving bithionol. A slight decrease in enzyme activity was encountered in Fasciola gigantica-infected control group 10 weeks post infection. In F. gigantica, bithionol treated group, a slight increase in alpha esterase activity was observed. It seems possible that bithionol administration in this group has overcome the decrease in enzyme activity caused by Fasciola worms. This could be considered as an indication that bithionol has an active therapeutic effect