role of mycoplasma in the pathogenesis of first trimester spontaneous abortion

ABSTRACT

This study was carried upon 20 women suffering from first trimester spontaneous abortion as a test group and 8 normal women with no history of abortion as a control group. From each women included, 2 samples were taken [a] an endocervical swab for isolation of Ureaplasma urealyticum [U.U] and Mycoplasma hominis [M.H,] by Mycofast ALL-IN technique, [b] blood sample for detection of serum mycoplasmal antibodies. The husbands of both groups were also tested for the presence of serum mycoplasmal antibodies. Isolation of U.U. form 35% of patients but nothing were obtained from the control group. No isolation of M..H from both patients or normal women had been detected. The D.B.V. international mycoplasma serology test showed that U.U. antibodies were found in 35% of aborted women and 15% of their husbands and M.H, antibodies were detected in 15% and 5% respectively. Of the control group, 25% of the women had antibodies of U.U. and 12.5% of them had antibodies of M.H. while their husbands have no antibodies at all. In general, mycoplasmal infection increases in old age group [40-45 ys] and with high gravidity. So, we conclude that these microorganisms play a role in the pathogenesis of first trimester spontaneous abortion