role of toxoplasma in repeated pregnancy wastage an experimental study in mice

ABSTRACT

Transplacental transmission of T. gondii was studied using peroxidase Antiperoxidase [PAP] and Hx and E., histologic examination of uteri and placentas of 90 experimentally infected female mice in 3 successive pregnancies. Their sera were also examined for specific IgM by double sandwitch IgM enzyme linked immunosorbent assay [DS-ELISA]. It was found that placental infection can occur in mice with parasitaemia [during primary infection] and in those which were not parasitaemic but their uteri showed setting of T. gondii in their muscular wall. This study suggests that similar situation can be found in human and may be responsible for habitual abortion and congenital infections of fetuses