Novel benzimidazole, benzothiazole and uracil derivatives as potential Antimicrobial agents

ABSTRACT

Hydrazinolysis of benzimidazole-2-thiol [la], benzothiazole-2-thiol [lb] and 6-methylthiouracil [lc] afforded the corresponding hydrazine derivatives II. These were condensed with the 1,3-dicarbonyl compounds III and V and alpha, beta-unsaturated carbonyl compounds VII giving compounds IV, VI and VIII, respectively. In addition, benzimidazole-2-thiol and benzothiazole-2-thiol were reacted with methyl chloroformate giving the S-carbonyl derivatives which upon reaction with hydrazine hydrate afforded the corresponding 2-[hydrazinocarbonyl] thio derivatives X. These acid hydrazides X were further condensed with the 1,3-dicarbonyl compounds III and V and alpha, beta-unsaturated carbonyl compounds VII giving compounds XI- XIII, respectively. Twelve of the newly synthesized compounds were evaluated for antimicrobial activity against variety of microorganisms