Synthesis of certain 9- [substituted amino] acridines potential antitumor agents

ABSTRACT

9-aminoacridine [I] was converted to variety of 9-N-heterocyclic IIIa,b, N-methylcarbamido Vc-g, ureido VI and hydroxyureido IX derivatives in connection with a program synthesizing potential antitumor agents derived from acridine. Representative examples of the products were tested for in vitro antitumor activity against Ehrlich ascites cells. Two products showed perspective activities