Synthesis of condensed heterocyclo [n,m-b] quinazolines
Alexandria Journal of Pharmaceutical Sciences. 1992; 6 (2): 227-230
em Inglês
| IMEMR
| ID: emr-22872
ABSTRACT
Condensation of the cyclic imidoyl chlorides; namely, 2-chlorobenzothiazole, 2-chloroquinoline, 2-chloro-4-methylquinoline, 2-chloropyridine and 2-chloro-3-methylquinoxaline with ethyl anthranilate afforded the corresponding 2-[2-ethoxycarbonylphenyl] aminoheterocycles IIIa-f. The products underwent cyclocondensation to the heterocycloquinazolines IVg-i upon heating above their melting points. Condensation of ethyl anthranilate with 2-chloro-4-arylphthalazines directly gave the corresponding quinazolinophthalazines. Attempted isolation of the cyclic intermediates was unsuccessful. The relatively less reactive 2-mercaptobenzimidazole underwent condensation with ethyl anthranilate only upon fusion at a relatively high temperature [300C] to give benzimidazoquinazoline. The structures of all products were assigned on the basis of elemental analysis, IR and PMR spectra
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Farmacocinética
/
Química
Idioma:
Inglês
Revista:
Alex. J. Pharm. Sci.
Ano de publicação:
1992
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