Helicobacter pylori associating upper gastro-intestinal diseases

ABSTRACT

Fifty patients with dyspeptic symptoms were studied for the presence of H. pylori organisms. They were subjected to UGI-Endoscopy. Biopsy specimens were taken from the pyloric antrum and first part of the duodenum and examined bacteriologically by Gram strain, urease test and cultures. In the 50 antral biopsies studied; H.pylori organisms were isolated by culture in 35 cases [70%]. In comparison with culture results; urease test revealed the presence of H. pylori in 33 cases [66%] with 94.3% sensitivity and 100% specificity. While Gram stain revealed the presence of H.pylori in 24 cases [48%] with 68.5% sensitivity and 100% specificity. According to endoscopic findings; H. pylori organisms were isolated in 35.7% of cases with normal gastro-duodenal mucosa; in 77.7% of cases with gastritis, in 75% of cases with duodenitis, in 94.44% of cases with duodenal ulcer and in 60% of cases with gastric ulcer. It was found that there was a significant association between H. pylori infection with both duodenal ulcers and gastritis