Synthesis hypotensive and antispasmoclic activities of certain aminomethyl chromones

ABSTRACT

Several drugs available for the treatment of hypertension lower the peripheral vascular resistance either through an inhibition of the sympathetic activity via an influence on adrenoreceptors in the CNS or a direct vasodilating effect on the smooth muscles in the arterioles. Khellin, the most important furochromone isolated from Ammi visnaga L., and its analogues exert a direct spasmolytic action on a variety of smooth muscles including those of blood vessels. Some of 6-aminomethyl derivatives of khellin and a combination of khellin and barbiturates produced sustained hypotensive action. On the other h and, antispasmodic and beta-adrenergic blocking action have been reported in several types of amino chromones. Accordingly, in a sustained effort to find cardiovascular and antispasmodic agents certain new aminomethylchromones and furochromones have been synthesized and tested for their hypotensive and antispasmodic activities