Holoprosencephaly: counselor dilemma

ABSTRACT

Three unrelated families having Holoprosencephaly [HP] in the index case were reported with different situations leading to counsellor dilemma. The first family has an unusual heritable balanced chromosome translocation. The second and third families follow a possible autosomal dominant and autosomal recessive modes respectively. This situations reflects the genetic heterogeneity of this disorder which complicates the counseling process