5-Methylthiazolo [5,4-d] pyrimidines: I-synthesis of newer thiazolopyrimidine derivatives with antimicrobial activity

ABSTRACT

5-methyl-2-[substituted thio] thiazolo [5, 4-d]-pyrimidinones 3 were obtained from reaction of 4-thiazolecarboxamides 1 with acetylacetone. Action of phosphorus oxychloride on 3 afforded 7-chlorothiazolo [5, 4-d] pyrimidines 4, upon reaction with hydrazinium hydroxide, gave the 7-hydrazino derivatives 5