Influence of vanadium on lipid profiles and lipid peroxidation in rat liver

ABSTRACT

Twenty four adult male Sprague-Dawley rats were administered sodium matavanadate [2.5 mg/kg body wt] for 7 consecutive days by intraperitoneal route. Results revealed significant diminution in the levels of phospholipids, cholesterol and cerebrosides, but significant increment in gangliosides contents in rat liver following vanadium-treatment. Occurrence of lipid peroxidation was also accelerated. These studies have implicated that vanadium-induced stimulation of lipid peroxidation was the event leading to oxidative degradation of lipids in rat liver. However, malfunctioning of gangliosides led to their increment