Liver biochemical profiles in hepatomegalic patients with diabetes mellitus

ABSTRACT

Liver biochemical tests regarding serum aminotrasnsfereases [AST, ALT], alkaline phospahatases[ALP], lactate dehydrogenase [LDH], gamma glutamyltransferase [GGT], cholesterol, total and conjugated bilirubin, total proteins and electrophoretic fractions were measured in 59 diabetic patients with hepatomegaly and a control group of 50 subjects without diabetes or hepatomegaly. Significant increases of SAST, SALT, SALP, SLDH, SGGT, and serum cholesterol were found in diabetics with hepatomegaly as compared to the diabetic with no hepatomegaly and the control group. There was also significant difference between total serum bilirubin concentration in hepatomegalic diabetics and controls, but no significant difference with those diabetic patients with normal liver size. The Level of serum albumin was significantly lower while alpha[1], alpha[2], beta and total globulins were significantly higher in hepatomegalic diabetics than in the control group