Experimental dilating cardiomyopathy and myocardial ionic changes in mice.

ABSTRACT

This study was designed to examine the myocardial ionic changes in experimental animal models of dilating cardiomyopathy induced by treating male balb-c mice either with cobalt chloride [2 mg/ kg, i.p] or tyramine HC1 [5 mg/kg i.p] once daily for 5 and 10 days. Age and weight matched mice were treated with distilled water served as controls. Our results showed that cobalt chloride and tyramine HC1 produced an increase in cardiac mass and non specific histopathological changes of congestive cardiomyopathy. The induction of cardiomyopathy was associated with significant alterations in myocardial ions which is related to the inducing agent. We conclude that the similarity and discrepency in myocardial ions levels in experimental dilating [congestive] cardiomyopathy is a part related to the causative agent