Antimicrobial activity of fusidic acid against some bacterial eye isolates

ABSTRACT

The in-vitro activity of fusidic acid against 113 bacterial eye isolated [107 gram positive and 6 gram negative] was investigated by agar dilution and both micro- and macrodilution methods. The results show that fusidic acid is very effective against all the gram-positive isolates with best inhibition against Staphylococcus aureus [non- penicillinase-producing] [MIC95 < 1.4 mug/ml]. All gram-negative isolates were sensitive to fusidic acid [MIC95 < mug/ml] with the exception of Pseudomonas spp. [MIC95 > 100 mug/ml]. It is concluded that fusidic acid proved to be an effective antibiotic for the treatment of bacterial eye infections caused by one of those susceptible strains