Some immuno physiological parameters in geriatrics

Peripheral blood lymphocytes from 20 apparently healthy males and females aged from 50-75 years were studied for age related changes in a number of immunological parameters. The results show some changes in these immunological parameters compared to young aged subjects determined in helper OKT[4] reduction [P 0.001] and OKT[4]/OKT[8] ratio. Also delayed type hypersenstivity more presented in less positive reactions in old than young subjects. Immunoglobulins study showed significantly elevated IgG [P 0.01] no statistically significant changes in complement and in immune complex in old age compared to young age. Comparison of results between males and females showed no difference in both cellular and humoral immunity. A programed involution of immune system [A biological Clock] in aged individual is accompanied by an increase in cancer, auto-immune diseases and an impairment of immunologic surveillance. It appears that malnutrition, thymic involution or an intracellular defects may be the main factors contributing to senile immunodeficiency