Study of the biocompatibility of Egyptian made aluminum oxide ceramic in experimental animals

ABSTRACT

The ossicular chain reconstruction has been a challenge to the otologist since a long time. In Egypt, we can manufacture with the cooperation of National Research Center a high Purity form of aluminum oxide ceramic which is nearly non porous. The aim of this study is to test the biocompitability of this Egyptian made aluminum oxide ceramic in experimental animals before using it clinically. Our results showed that, the material is suitable for implantation in experimental animals without including foreign body reaction or rejection. It is nondegradable, not affected with infection and does not fix to surrounding structures. So, Egyptian made aluminum oxide ceramic is suitable for using it in reconstruction of ossicular chain. However, the clinical evaluation of its use in human being will be done in further study