comparative study on the effect of administration of fentanyl with [thiopentone or propofol on intra-ocular pressure changes during induction and intubation]

ABSTRACT

Intraocular pressure was measured durning induction of anaesthesia with propofol [n=40] or thiopentone [n=40]. The average induction dose were 2.15 and 4.83 mg Kg [-1] for propofol and thiopentone. Half the patients in each group received 100 ug Fentanyl with thiopentone and propofol. Both propofol and thiopentone produced a significant reduction in intraocular pressure which decreased further after administration of Fentanyl. Intraocular pressure prior to intubation was lower in the two propofol groups in comparison to the corresponding thiopentone groups. Intubation was associated with an increase in intraocular pressure but it still remained significant below the baseline values except in the group given thiopeentone only. Fentanyl given with the induction agents attenuate the increase in intraocular pressure associated with intnbation. Propofol was significantly more effective in this respect and this group showed the lowest intraocular pressure throughout the study period. However, administration of popofol resulted in a 30% incidence of pain on injection and a decrease in systolic arterial pressure of more than 30% in about half the patients [most of them in the group that received fentanyl with propofol]