Role of mast cell in pathogenesis of exercise induced asthma

ABSTRACT

Mast cell with its potent mediators plays a central role in allergen- induced bronchial asthma, to assess its role in the pathogenesis of exercise-induced asthma. A specific sensitive marker as serum neutrophil chemotactic activity was assessed as a direct evidence for its activation. The serum neutrophil chemotactic activity was assessed before and after 10 minutes of standardized exercise which is the best non pharmacological, non immunological stimulus for airway obstruction in patients with asthma. Twenty-four of them proved to have asthma precipitated by exercises. The other 12 were no exercise- induced asthma, another 10 healthy controls were taken for comparison