Biochemical study of hepato-renal toxicity of amikacin and netilmicin in rats

ABSTRACT

The effect of short term parenteral medication of two types of aminoglycosides; namely, amikacin and netilmicin, on adult male albino rats maintained over 3 weeks in doses equivalent to human therapeutic dosage, were studied. Metabolic derangements, evoked by these drugs therapy, were reflected by significant rise in serum aspartate transaminase [AST-GOT], serum alanine transaminase [ALT- GPT], alkaline phosphatase [ALP] and bilirubin. Also, medication with the aforementioned drugs caused persistent hyperlipidemic effect, accompanied with significant increases in serum phospholipids, triacylglycerol and cholesterol. Except, netilmicin produced reduction in serum cholesterol. However, amikacin produced increase in serum total protein and globulin, but delayed onset of increase till 14 days, yet, netilmicin produced increase in serum globulin and decrease in serum albumin during all the experimental period. Both drugs significantly elevated serum creatinine and blood urea nitrogen