Comparative study of hepato-renal toxicity of some cephalosporin in rats

ABSTRACT

Daily parenteral velosef and cefobid medication for adult male rats, maintained over 21 days in rodent equivalent of human therapeutic dosages caused metabolic derangement reflected by significant rise in serum total cholesterol triacylglycerol, accompanied with delayed onset of increase in serum phospholipids up to 14 days of experiment. Cefobid, showed decrease in serum albumin coupled with predominant increase in globulin during the whole experimental period. Both drugs significantly increased creatinine and blood urea nitrogen levels, but the onset of increase delayed up to 14 days in case of velosef therapy. Serum aminotransferases [Asp-At and Ala-At] were significantly increased by both medication, but the increase delayed till the 14th day in case of velosef. Medication with cefobid produces initial reduction in alkaline phosphatase [ALP] after 7 days, followed by increase till the end of experiment, in contrast, velosef increases ALP level only after 7 days of treatment. Serum bilirubin level was significantly increased in case of cefobid with peak value after 7 days