Biochemical effects of desferrioxamine in hepatic cells of Swiss albino mice

ABSTRACT

Desferrioxamine [DFO] used as a chelator in treatment of chronic iron over load diseases was evaluated for its effects on proteins and nucleic acid contents in hepatic cells of mice on acute and sub - acute treatment. The acute treatment of DFO failed to significantly affect the levels of proteins and nucleic acids in hepatic cells. However, on sub - acute administration for 7 days, DFO was found to reduce the levels of RNA and DNA compared to control. These changes were statistically insignificant; however the results clearly indicated the weak cytotoxic potentials of DFO on sub - acute treatment