comparative study of bioavailabilities of different brands of chloramphenicol

ABSTRACT

Different drug manufacturers claim better quality and bioavailability of the similar dosage from of a drug product. In view of this, the bioavailability of four different brands of chloramphenicol was investigated in ninty six albino rabbits of either sex with an average body weight of 2.5 +/- 0.1 kg. Each brand of chloramphenicol was administered to a group of twenty four rabbits and blood concentrations were estimated using the spectronic-20 spectrophotometer at 430 nm against water blank. The study revealed that the bioavailability of brand 'A' of chloramphenicol was significantly higher compared with brands 'B', 'C' and 'D' which did not differ significantly form each other